尽管，不管(in spite of)：(finish a job)～the rain/the bad weather/one's serious illness尽管下雨/天气不好/病得很重(还是把活干完了);(fail)～all one's efforts 尽管尽了最大努力(还是失败了);(not get a job)～all one's qualifications 尽管条件完全符合(还是没有得到一份工作);～what others say/the fact... 不管别人怎么说/尽管事实上……;〖同〗in spite of;

【辨异】despite与in spite of同义，且可互换，只是语体色彩有别：despite语体色彩较为正式;in spite of见于非正式语体。